You have got your plot lines worked out and your characters fully drawn. This new plot horror will be good for leading a good guy into serious mistakes (I'm thinking maybe Glaselle) and opening some interesting, foreshadowing questions (How do we tell history about this? Maybe we shouldn't?)
But the culmination of the thread needs to wait until Hell comes for things, handbasket in hand. I can't leave too much time to brood on this one, because folly-made disaster must follow fast and faster.