Until someone can give me an example whereby putting in that last serial (Oxford) comma confuses the meaning instead of clarifying it, I'll be an Oxford comma writer! There's no reason not to use it, IMO, other than a determination to avoid commas at all cost. And then the onus would be on the anti-Oxford comma writer to make sure the sentence doesn't give the reader the pause he was trying to avoid in the first place.
Hear, hear! Anything that clarifies meaning is a boon to writers. There are way too many authors who assume commas are optional, or worse yet, merely decorative. If you're not sure how to punctuate, you need to find a reliable editor.
In AZ, back seat passengers are not required to use their seat belts. That doesn't mean they'd be better off without them. Same with the Oxford comma. Do everything you can to insure your readers' experience.