I had a girlfriend of main character in certain of my work who i based on one close friend and my real life girlfriend. While the story progressed I had to make decision to let this girl killed. I was really attached to her not only by her character but also this real life connection. Then 2-3 years later this close friend of my died for cancer (at age of 16) and while after that I broke up with my girlfriend. Both of these events affected of course my writing and further development of this character prior her death.